kpl外围

邓诣群教授团队揭示了FOXM1信号通路的新型调控机制

发布者: 生命科学学院发布时间: 2019-06-29浏览次数: 40

       近日,kpl外围校生命科学学院、岭南现代农业科学与技术广东省实验室、广东省农业生物蛋白质功能与调控重点实验室邓诣群教授团队和中山大学附属肿瘤医院华南肿瘤学国家重点实验室朱孝峰教授课题组合作在国际著名学术期刊 Gastric Cancer (IF2019 = 7.088)在线发表题为“Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway”的论文,揭示了细胞增殖关键基因FOXM1的新型调控机制及针对该通路的药物联合协同作用机理。(论文链接地址: http://link.springer.com/article/10.1007/s10120-020-01097-x)



kpl外围        XIBAOZENGZHISHISHENGWUTISHENGZHANG、FAYU、FANZHIHEYICHUANDEJICHU。FOXM1SHIKONGZHIXIBAOZENGZHIDEGUANJIANJIYINZHIYI,QIYICHANGJIHUOYUAIXIBAOZENGZHIHEFENLIEMIQIEXIANGGUAN,YICHENGWEIYAOWUKAIFADEZHONGYAOBADIAN。DENGYIQUNJIAOSHOUTUANDUIHEZHUXIAOFENGJIAOSHOUTUANDUIHEZUOFAXIANFOXM1DEXINXINGDIAOKONGTUJING,JIEZH2-ERRγ-FOXM1XINHAOTONGLU。YANJIUFAXIAN,CIJISUXIANGGUANSHOUTIERRγSHIFOXM1DEYIGEXINXINGFUDIAOKONGYINZI,TONGGUOZHIJIEJIEHEZAIFOXM1DEQIDONGZISHANG,YIZHIFOXM1DEBIAODA,ERERRγDEBIAODAYOUSHOUZUDANBAIH3K27me3MEIEZH2DEFUDIAOKONGYIZHI。FOXM1HEEZH2ZAIWEIAIXIBAOZHONGGAOBIAODA,QIEYUWEIAIBINGRENDEYUHOUFUXIANGGUAN,ERRγZAIWEIAIXIBAOZHONGDIBIAODA,QIEYUWEIAIBINGRENDEYUHOUZHENGXIANGGUAN。JINYIBUYANJIUFAXIAN,EZH2DEYIZHIJIGSK126YUERRγDEJIDONGJIDY131LIANHESHIYONG,KEXIANZHUXIETONGYIZHIFOXM1DEBIAODA,CONGERYIZHIWEIAIXIBAODEZENGZHIHEXIAOSHUWEIAIYIZHILIUDESHENGZHANG。GAIYANJIUJIESHILEXIBAOZENGZHIDIAOKONGGUANJIANJIYINFOXM1DEXINXINGDIAOKONGTONGLU,BINGZHENGSHILEZHENDUIGAITONGLUDEYAOWULIANHEZUOYONGXIAOGUO,JUYOUZHONGYAODELILUNYIYIHEYINGYONGJIAZHI。


ZH2- ERRγ-FOXM1XINHAOTONGLUJIGSK126YUDY131DEXIETONGZUOYONGJILI


   BENLUNWENDETONGXUNZUOZHEWEIDENGYIQUNJIAOSHOU,ZHONGSHANDAXUEFUSHUZHONGLIUYIYUANZHUXIAOFENGJIAOSHOUWEIGONGTONGTONGXUNZUOZHE。DENGYIQUNJIAOSHOUBOSHISHENGHUANGBOYANHETUANDUIGUGANMUPEIQIANGFUYANJIUYUANWEILUNWENGONGTONGDIYIZUOZHE。GAIYANJIUDEDAOLEGUANGDONGSHENGZIRANJIJINTUANDUIXIANGMU、GUANGZHOUSHIKEJIJIHUAZHONGDIANXIANGMUHEGUANGDONGSHENGPUTONGGAOXIAOCHUANGXINTUANDUIXIANGMUDEZHICHI。(WENTU/ MUPEIQIANG)

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